Yes, you can combine multiple targeting categories within a single ad set. However, this approach is generally not recommended, as it can significantly reduce your ad set's reach.

When multiple targeting categories are selected (for example, Interest, Fan, Genre, and Contextual targeting), Ads Manager uses AND logic. This means a listener must meet all selected criteria in order to be eligible to receive your ad.

For example, if you combine Interest, Fan, Genre, and Contextual targeting, a listener must match the selected interest, be a fan of the specified artist, be listening to the selected genre, and be engaging in the selected real-time context at the same time.

Because each additional targeting layer narrows the eligible audience, combining multiple targeting categories can limit delivery and make it more difficult for your campaign to reach its full potential.